This makes it difficult to predict who will respond well and who will be intolerant to the drug. As a result, patients suffering from these debilitating conditions have variable response and adverse effect profiles to these drugs. However, these drugs often interact with different brain targets in various central nervous system regions. Medications used in the treatment of neurodegenerative and neuropsychiatric disorders, such as Alzheimer's, schizophrenia and Parkinson's disease, often target specific receptors or enzymes in affected brain areas. She is involved in publications and knowledge translation activities designed to enhance clinicians' understanding of qualitative research in health care and related research. Kuper also has an interest in the medical humanities, both as an understudied pedagogical resource and as a potential point of intersection with non-traditional avenues (e.g., cultural theory) for exploring research questions that are relevant to educators and clinicians. She is also interested in specific effects of the currently accepted knowledge production modalities on the legitimacy of particular subject areas within mainstream medical education research, as well as in the potential effects of broadening the field's legitimate methodologies on medical education research and medical education practice.ĭr. Kuper's current research program addresses the origins and history of the field of medical education research and the effects of that history (e.g., sociohistorical factors and the struggle for legitimacy between disciplines and methods) on the definition of legitimate knowledge production within this field. His current research interests extend to the implementation of knowledge about thromboembolism into clinical practice. This study demonstrated that the early use of low molecular weight heparin is more efficacious than low-dose heparin in trauma patients without increasing bleeding. Geerts and his group conducted the first large randomized trial of thromboprophylaxis in major trauma patients, by comparing subcutaneous low-dose heparin with low molecular weight heparin in a double-blinded manner. He has performed the most comprehensive, prospective study of the risks of venous thromboembolism in trauma patients and found that they are the highest-risk group for thromboembolism in hospitals. His primary interest has been in the prevention of venous thromboembolism (VTE) in high-risk patients, especially following trauma. Geerts has developed and participated in clinical research in all aspects of thromboembolism, including epidemiology, diagnosis, treatment and prevention.
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